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. Author manuscript; available in PMC: 2020 Apr 18.
Published in final edited form as: Mol Cell. 2019 Apr 4;74(2):393–408.e20. doi: 10.1016/j.molcel.2019.02.003

Scheme 1:

Scheme 1:

a) Diisopropylamine, n-BuLi, ethyl formate, THF, −78 °C; b) Ammonium hydroxide, 1,4-Dioxane, 60 °C; c) K3PO4, PdCl2(dppf)2. 4-Chlorophenylboronic acid, 1, 4-Dioxane/H2O, 85 °C (microwave); d) K3PO4, PdCl2(dppf)2. 4-Phenoxyphenyl boronic acid, 1, 4-Dioxane/H2O, 85 °C (microwave); e) 2-cyano-N-isopropylacetamide, DB U, THF, RT.