Table 1:
Neuroprotective potential of proteins identified in the Green cluster.
| UniProt ID | Gene Symbol Human | Protein name | Potential Neuroprotective Functions | Refs. |
|---|---|---|---|---|
| Q15848 | ADIPOQ | Adiponectin | Primes transition to M2 macrophages, reduces oxidative stress, shown to be protective in mouse models of cerebral ischemia | [42,48, 49] |
| P00488 | F13A1 | Coagulation Factor XIII A Chain | M2 macrophage marker, increases macrophage phagocytosis capability | [39] |
| O60243 | HS6ST1 | Heparan sulfate 6-O Sulfotransferase 1 | Neuronal axon patterning | [57] |
| Q08397 | LOXL1 | Lysyl oxidase Like 1 | Stabilizes the extracellular matrix | [59] |
| P11226 | MBL2 | Mannose Binding Lectin | Immunosuppressive, binds apoptotic and necrotic cells to facilitate macrophage phagocytosis and induces macrophage secretion of immunosuppressive cytokines. | [43,44] |
| Q9H8L6 | MMRN2 | Multimerin 2 | Angiogenesis | [56] |
| P02763 | ORM1/ AGP1 | Orosomucoid 1/ Alpha-1-Acid Glycoprotein 1 | Immunosuppression, increases CD163 a M2 macrophage marker | [41] |
| Q14435 | GALNT3 | Polypeptide N-Acetylgalactosaminyltransferase 3 | Protects endothelial cells | [58] |
| P04278 | SHBG | Sex hormone-binding globulin | Glucose metabolism | [50] |
| Q9NY15 | STAB1 | Stabilin 1 | M2 macrophage marker, increases macrophage phagocytosis capability. Angiogenesis | [40,55] |
| O95183 | VAMP5 | Vesicle Associated Membrane Protein 5 | Involved in vesicle transport of the glucose transporter, GLUT4 | [52] |
| P04217 | A1BG | Alpha-1-B Glycoprotein | ||
| P01591 | JCHAIN | Immunoglobulin J Chain | ||
| P15814 | IGLL1 | Immunoglobulin Lambda Like Polypeptide 1 | ||
| Q9UKX2 | MYH2 | Myosin Heavy Chain 2 | ||
| Q5T1S8 | NCMAP | Non-compact Myelin associated protein |