Figure 3.

Adropin reduces whole‐body insulin‐stimulated glucose uptake in obese mice. (A) Whole‐body glucose uptake was significantly decreased in adropin (Adr)‐treated obese mice relative to high‐fat diet (HFD) controls under hyperinsulinemic conditions. (B) There was a small, but nonsignificant decrease in glucose uptake in the gastrocnemius of adropin‐treated HFD mice. (C) Furthermore, there was no change in quadricep glucose transport between the HFD mouse groups. N = 6–8; *P < 0.05 versus vehicle‐treated HFD.