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Adropin improves hepatic insulin sensitivity in obese mice during hyperinsulinemia. (A) There was a decrease in hepatic glucose production under both basal and hyperinsulinemic conditions in adropin (Adr) mice. (B–H). Adropin treatment suppressed expression of hepatic fatty acid uptake (CD36 and CPT1a), PDH‐inhibitory (PDK4), and gluconeogenic (G‐6‐Pase) proteins in high‐fat diet (HFD) diet mice. N = 4–8; *P < 0.05 versus vehicle‐treated HFD.
