Table 3.
Epigenome-wide association study results for CpG sites that yielded associations within a 5% (**) or 10% (*) FDR for either the optimal or atypical NNNS profile groupings; beta coefficients (β1) represent the mean difference in methylation proportion when comparing the optimal or atypical NNNS profiles to the rest of the NOVI sample.
| CpG Annotations | Optimal NNNS Profile | Atypical NNNS Profile | ||||
|---|---|---|---|---|---|---|
| CpG | Location | Gene | β1 | P-value | β1 | P-value |
| cg25755851 | chr1:9335794 | — | −0.013 | 1.89E-01 | −0.032 | 2.53E-06* |
| cg22960767 | chr1:37422679 | GRIK3 (Body) | 0.022 | 1.39E-02 | 0.036 | 3.55E-06* |
| cg26057754 | chr1:183774231 | RGL1 (Body) | −0.001 | 7.00E-01 | −0.004 | 7.38E-07* |
| cg23264395 | chr1:207096239 | FCMR (TSS1500) | 0.001 | 8.50E-01 | 0.034 | 2.48E-06* |
| cg01479768 | chr2:731298 | — | −0.006 | 6.91E-01 | 0.045 | 2.20E-06* |
| cg08902894 | chr2:3142407 | — | 0.002 | 7.22E-01 | 0.029 | 1.10E-07* |
| cg05696361 | chr2:107108978 | — | 0.003 | 7.78E-01 | 0.048 | 2.79E-07* |
| cg17505883 | chr2:130552292 | — | 0.006 | 2.59E-01 | 0.021 | 1.94E-06* |
| cg03046148 | chr3:13695666 | LOC285375 (Body) | 0.015 | 1.43E-07* | 0.003 | 4.56E-01 |
| cg07193729 | chr4:176031198 | — | 0.006 | 5.03E-02 | 0.014 | 3.07E-07* |
| cg02236672 | chr5:132449216 | — | −0.001 | 9.31E-01 | 0.037 | 9.98E-07* |
| cg00210856 | chr5:158466226 | EBF1 (Body) | 0.001 | 9.23E-01 | 0.028 | 4.29E-07* |
| cg02057469 | chr7:95951623 | SLC25A13 (TSS200) | −0.001 | 1.19E-01 | −0.004 | 3.05E-06* |
| cg04524088 | chr7:127847835 | MIR129-1 (TSS200) | −0.016 | 1.68E-01 | 0.045 | 2.27E-06* |
| cg17287134 | chr7:154959606 | — | −0.008 | 4.52E-01 | 0.040 | 1.01E-06* |
| cg21672855 | chr8:135614777 | ZFAT (Body) | −0.002 | 1.73E-01 | 0.005 | 1.71E-06* |
| cg14632902 | chr9:139017648 | — | 0.012 | 1.91E-02 | 0.026 | 3.49E-06* |
| cg06846137 | chr10:131682939 | EBF3 (Body) | 0.004 | 4.20E-01 | 0.019 | 1.36E-06* |
| cg13716458 | chr11:28997975 | — | 0.006 | 6.38E-02 | 0.020 | 5.51E-07* |
| cg07895260 | chr12:55537168 | — | −0.001 | 9.37E-01 | 0.034 | 3.19E-06* |
| cg27361636 | chr12:120502417 | BICDL1 (Body) | −0.001 | 9.20E-01 | 0.044 | 2.93E-06* |
| cg23172057 | chr13:113800351 | F10 (Body) | 0.010 | 1.55E-01 | 0.030 | 5.43E-08** |
| cg11042421 | chr14:42881184 | — | 0.006 | 4.29E-02 | 0.015 | 2.71E-06* |
| cg14354244 | chr14:51446038 | TRIM9 (Body) | 0.006 | 5.04E-01 | 0.034 | 3.66E-06* |
| cg03444659 | chr14:94834215 | SERPINA2 (TSS1500) | −0.002 | 7.14E-01 | 0.015 | 1.43E-06* |
| cg14792155 | chr15:42289618 | PLA2G4E (Body) | −0.007 | 7.50E-01 | 0.106 | 4.04E-06* |
| cg02187389 | chr16:1247777 | CACNA1H (Body) | 0.000 | 9.97E-01 | 0.024 | 7.96E-07* |
| cg02234314 | chr19:55986224 | ZNF628 (TSS1500) | 0.003 | 7.85E-01 | 0.059 | 2.08E-06* |
| cg07850633 | chr20:15795880 | MACROD2 (Body) | 0.017 | 3.49E-01 | −0.065 | 1.49E-06* |
| cg09772858 | chr22:49549729 | — | 0.006 | 4.15E-01 | 0.030 | 2.52E-06* |
CpG = cytosine-phosphate-guanine methylation site, FDR = False Discover Rate, NNNS = NICU Network Neurobehavioral Scale; For CpGs with no annotated genes, we annotated this with the nearest genes within 2500 bp of the CpG.