Table 4.
Pathways involved in neurodevelopment and/or neuronal activity that were significantly (FDR < 0.10) over-represented among the genes annotated to the top 250 CpGs that associated with the Atypical NNNS profile.
| Pathway ID | Pathway Description | Total Genes | NNNS-Associated Genes | P-val. | FDR Q-val. |
|---|---|---|---|---|---|
| path:hsa04724 | Glutamatergic synapse - Homo sapiens (human) | 114 | PLCB1; GRIK3; PRKCB; PLA2G4E; ADCY3 | 0.0020 | 0.026 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 152 | PLCB1; GRIK3; AP2A2; PRKCB; ADCY3 | 0.0069 | 0.040 |
| R-HSA-416993 | Trafficking of GluR2-containing AMPA receptors | 17 | PRKCB; AP2A2 | 0.0077 | 0.040 |
| R-HSA-112316 | Neuronal System | 367 | PLCB1; PRKCB; PTPRS; KCNK9; ADCY3; GRIK3; AP2A2; KCNA3 | 0.0082 | 0.041 |
| ngfpathway | nerve growth factor pathway (ngf) | 18 | PLCG1; NGFR | 0.0086 | 0.043 |
NNNS = NICU Network Neurobehavioral Scale; FDR = False Discover Rate.