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. 2019 Apr 19;9:6316. doi: 10.1038/s41598-019-42838-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Chemical inhibitor screen identifies oncoproteins relevant to MS1 VEGF angiosarcoma cell proliferation and survival. (a–c) Mean data showing the effect of various chemical inhibitors of the indicated proteins on cell number (a), viability (b), and proliferation determined by MTS assay (n = 4). The chemical inhibitors (and concentrations) used were: PI3K - LY294002 (10 μM), Akt - Akt1/2 kinase inhibitor (10 μM), Bcl-2 - TW37 (1 μM), VEGFR - SU1498 (10 μM), ERK - PD98059 (10 μM), survivin - YM155 (1 μM), mTOR - temsirolimus (1 μM), and FGFR – SU5402 (10 μM). Fenofibrate (50 μM) was used as a positive control in the screen. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s multiple comparisons test. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; n.s, not significant.