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. 2019 Apr 19;9:6319. doi: 10.1038/s41598-019-42825-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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JAK/STAT pathway activity promotes AnCPV infection in Anopheles coluzzii. Effect of STAT-A silencing on AnCPV prevalence is indicated as a proportion in two biological replicates ((A) replicate 1, (B) replicate 2). dsSTAT-A indicates mosquitoes injected with double-stranded RNA directed against STAT-A transcript, and dsGFP indicates mosquitoes injected with irrelevant dsRNA. X-axis, dsRNA treatment, y-axis, AnCPV infection prevalence. (n) indicates the total number of mosquitoes for each of the 2 replicates. Statistical differences were first tested independently within replicates by the Wilcoxon-Mann-Whitney test using 100,000 permutations to assess the p-value (given above each plot). Individual replicates displayed a consistent direction of change, and consequently individual p-values were combined using the method of Fisher to generate a combined p-value (combined p = 0.02, chi-square = 11.4, df = 4). Detailed statistics in Supplementary Table S4.