Table 2.
Descriptive Statistics for Brain and retinal imaging-derived measurements in the Lothian Birth Cohort 1936 and the Mild Stroke Study: M (SD) for Continuous Variables and N (%) for Categorical Variables.
| Variable | Lothian Birth Cohort 1936 | Mild Stroke Study |
|---|---|---|
| Brain measurements, mean (SD) | ||
| WMH % in BTV | 1.00 (1.11) | 1.69 (2.05) |
| WMH % in ICV | 0.77 (0.85) | 1.33 (1.62) |
| Ratings | ||
| Fazekas score (periventricular) | ||
| 0 | 17 (4) | 6 (4) |
| 1 | 310 (66) | 69 (48) |
| 2 | 116 (24) | 41 (28) |
| 3 | 28 (6) | 29 (20) |
| Fazekas score (deep white matter overall) | ||
| 0 | 77 (16) | 22 (15) |
| 1 | 306 (65) | 79 (54) |
| 2 | 77 (16) | 21 (15) |
| 3 | 11 (2) | 23 (16) |
| PVS (basal ganglia) | Range: 0–3 | Range: 0–1* |
| 0 | 1 (0) | 87 (60) |
| 1 | 279 (60) | 57 (40) |
| 2 | 173 (37) | — |
| 3 | 14 (3) | — |
| Microbleeds | ||
| 0 | 420 (90) | 122 (85) |
| 1 | 47 (10) | 22 (15) |
| SVD score | ||
| 0 | 220 (47) | 69 (48) |
| 1 | 164 (35) | 27 (19) |
| 2 | 68 (15) | 29 (20) |
| 3 | 15 (3) | 14 (10) |
| 4 | 0 | 5 (3) |
| Retinal measurements, mean (SD) | ||
| CRAE | 31.19 (2.19) | 30.93 (2.80) |
| CRVE | 42.12 (3.16) | 43.67 (3.59) |
| BSTDa | 2.20 (0.64) | 2.10 (0.65) |
| BSTDv | 3.94 (0.86) | 4.01 (0.90) |
| FDa | 1.59 (0.05) | 1.59 (0.05) |
| FDv | 1.57 (0.04) | 1.58 (0.04) |
| TORTa (log transformed) | −9.98 (0.96) | −10.01 (0.88) |
| TORTv (log transformed) | −9.91 (0.69) | −9.76 (0.73) |
| BCa | 2.09 (0.22) | 2.14 (0.30) |
| BCv | 1.98 (0.24) | 1.98 (0.33) |
| LDRa | 19.37 (5.04) | 21.81 (11.21) |
| LDRv | 18.91 (4.96) | 19.55 (5.36) |
| AFa | 0.92 (0.04) | 0.90 (0.05) |
| AFv | 0.90 (0.05) | 0.88 (0.06) |
Note. BTV = brain tissue volume; ICV = intracranial volume; PVS = perivascular spaces (in basal ganglia); *0: none-mild; 1: moderate-severe. SVD = small vessel disease; CRAE = central retinal arteriolar equivalent; CRVE = central retinal vein equivalent; BSTDa = standard deviation of arteriolar widths in Zone B; BSTDv = standard deviation of venular widths in Zone B; FDa = arteriolar fractal dimension; FDv = venular fractal dimension; TORTa = arteriolar tortuosity; TORTv = venular tortuosity; BCa = arteriolar branching coefficient; BCv = venular branching coefficient; LDRa = arteriolar length diameter ratio; LDRv = venular length diameter ratio; AFa = arteriolar asymmetry factor; AFv = venular asymmetry factor.