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. 2019 Mar 1;8(5):e011628. doi: 10.1161/JAHA.118.011628

Figure 2.

Figure 2

Effect of 2ME2 on development of pulmonary hypertension in the chronic‐hypoxic rat model. Effects of 2ME2 on RVSP in female (A) and male rats (B). Effects of 2ME2 on right ventricular hypertrophy in female (C) and male rats (D) and pulmonary artery remodeling with representative photomicrographs of lung sections stained with elastin‐picrosirius red in female (E) and male rats (F). Data are shown as mean±SEM. All groups n=5; *P<0.05; **P<0.01; ***P<0.001 determined by 1‐way ANOVA followed by Tukey's post hoc test. Scale bar indicates 70 μm. 2ME2 indicates 2‐methoxyestradiol; Hx, hypoxic; Nx, normoxic; RVSP, right ventricular systolic pressure; Veh, vehicle.