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. 2019 Mar 1;8(5):e011628. doi: 10.1161/JAHA.118.011628

Figure 3.

Figure 3

Effects of 2ME2 on HIF1α expression in female hypoxic rat lung. Effects of 2ME2 on whole lung protein expression of HIF1α (A) with representative immunoblot (B) and whole lung HIF1α mRNA transcript expression (C) (n=4). Representative micrographs of HIF1α expression in distal pulmonary arteries in normoxic vehicle, normoxic 2ME2 treated, hypoxic vehicle and hypoxic 2ME2 treated rats (D). Data are shown as mean±SEM. *P<0.05 determined by 1‐way ANOVA followed by Tukey's post hoc test. 2ME2 indicates 2‐methoxyestradiol; HIF1α, hypoxia‐inducible factor‐1‐α; Hx, hypoxic; Nx, normoxic; Veh, vehicle. Scale bar indicates 20 μm.