Figure 2.

Mechanisms of regression following apo B lipoprotein reduction. Dramatic reduction in plasma concentrations of LDL‐C and other apo B lipoproteins leads to decreased subendothelial entry and retention. Decreased levels of “toxic” apo B lipoproteins allows normal phagocytic and inflammation resolving mechanisms to “heal” the plaque. Decreased foam cell formation in the intima allows macrophages to migrate into adventitial lymphatics. Increased in‐migration of monocytes that become healthy macrophages results in effective efferocytosis to remove necrotic debris. Apo indicates apolipoprotein.