Table 6.

Univariable and Multivariable Analyses of Association Between Number of Detected Variants and Clinical Outcomes

Variable	Univariable			Multivariablea
	HR	95% CI	P Value	HR	95% CI	P Value
Multiple vs single variant
Death and heart transplantation	1.27	0.36–4.47	0.710	···	···	···
All‐cause death	0.89	0.24–3.29	0.860	···	···	···
Heart transplantation	NAb	NA	NA	···	···	···
Cardiovascular death	0.89	0.24–3.29	0.860	···	···	···
Sudden cardiac death	NAc	NA	NA	···	···	···
Heart failure–related death	0.80	0.21–3.04	0.748	···	···	···
Single vs no variant
Death and heart transplantation	2.70	1.23–5.94	0.013	2.45	1.08–5.54	0.032
All‐cause death	1.87	0.79–4.46	0.156	···	···	···
Heart transplantation	NA	NA	NA	···	···	···
Cardiovascular death	1.87	0.79–4.46	0.156	···	···	···
Sudden cardiac death	0.78	0.08–7.55	0.833	···	···	···
Heart failure–related death	2.56	0.96–6.86	0.061	···	···	···
Multiple vs no variant
Death and heart transplantation	2.34	0.65–8.41	0.191	···	···	···
All‐cause death	2.34	0.65–8.41	0.191	···	···	···
Heart transplantation	NA	NA	NA	···	···	···
Cardiovascular death	2.34	0.65–8.41	0.191	···	···	···
Sudden cardiac death	NA	NA	NA	···	···	···
Heart failure–related death	3.73	0.96–14.45	0.057	···	···	···

CI indicates confidence interval; HR, hazard ratio; NA, not applicable.

^aItems with P<0.05 in univariable analyses were then included in the calculation of multivariable HR and 95% CI.

^bNo heart transplantation occurred in multiple variant carriers or noncarriers, so HR and 95% CI are not available.

^cNo sudden cardiac death occurred in multiple variant carriers, so HR and 95% CI that refer to this group are not available.