Table 1.
Patient Characteristics
| Sepsis Death (n=173) | Nonsepsis Death (n=540) | All‐Cause Death (n=737) | Survivors (n=1065) | |
|---|---|---|---|---|
| Age, y | 75.2 (0.7)a | 73 (0.4) | 73.5 (0.4)b | 67 (0.4) |
| Heart rate, bpm | 76.8 (1.4) | 74.1 (0.8) | 74.8 (0.7) | 75.7 (0.6) |
| QRS interval, ms | 127 (3) | 125 (1) | 126 (1)b | 121 (1) |
| Hemoglobin, g/dL | 13 (0.1) | 13 (0.1) | 13 (0.1)b | 13.8 (0.1) |
| WCC, ×109/L | 8.03 (0.19) | 7.89 (0.14) | 7.94 (0.11)b | 7.64 (0.06) |
| Lymphocytes, ×109/L | 1.67 (0.09) | 1.54 (0.03) | 1.58 (0.03)b | 1.82 (0.02) |
| Neutrophils, ×109/L | 5.42 (0.15) | 5.37 (0.1) | 5.4 (0.08)b | 4.9 (0.05) |
| Platelets, ×109/L | 257 (6)a | 237 (3) | 243 (3) | 248 (2) |
| Sodium, mmol/L | 138.9 (0.3) | 138.8 (0.2) | 138.8 (0.1)b | 139.8 (0.1) |
| eGFR, mL/(kg·min) | 51.6 (1.4) | 50.6 (0.8) | 50.9 (0.7)b | 62.5 (0.6) |
| Albumin, g/L | 42.1 (0.2) | 42 (0.2) | 42 (0.1)b | 43.6 (0.1) |
| Vitamin D, nmol/L | 26 (16‐46) | 30 (20‐47.7) | 29.5 (19.8‐46.8)b | 35 (21‐54.1) |
| LVEF, % | 32.2 (0.7) | 30.9 (0.4) | 31.3 (0.4)b | 32.5 (0.3) |
| Ramipril dose, mg/d | 4.1 (0.3) | 4.7 (0.2) | 4.5 (0.1)b | 5.2 (0.1) |
| Bisoprolol dose, mg/d | 3 (0.2) | 3.4 (0.1) | 3.3 (0.1)b | 4.3 (0.1) |
| Furosemide dose, mg/d | 59.9 (3.4) | 65.4 (2.3) | 64 (1.9)b | 42.4 (1.4) |
| MRA prescription, n (%) | 60 (34.7) | 224 (41.6) | 297 (40.4) | 392 (36.9) |
| Male sex, n (%) | 133 (76.9) | 424 (78.5) | 577 (78.3)b | 742 (69.7) |
| Diabetes mellitus, n (%) | 49 (28.3) | 185 (34.3) | 242 (32.8)b | 262 (24.6) |
| COPD, n (%) | 59 (34.1)a | 99 (18.3) | 167 (22.7)b | 117 (11) |
| Ischemic etiology, n (%) | 111 (64.2) | 373 (69.1) | 503 (68.2)b | 564 (53) |
| ICD (n [%]) | 16 (9.2) | 67 (12.4) | 85 (11.5) | 125 (11.7) |
| CRT (n [%]) | 48 (27.7) | 140 (25.9) | 196 (26.6) | 259 (24.3) |
| NYHA class | ||||
| 1, n (%) | 14 (8.1) | 56 (10.4) | 74 (10.1)b | 259 (24.3) |
| 2, n (%) | 79 (45.7) | 260 (48.3) | 353 (48) | 559 (52.5) |
| 3, n (%) | 77 (44.5) | 207 (38.5) | 290 (39.5) | 244 (22.9) |
| 4, n (%) | 3 (1.7) | 15 (2.8) | 18 (2.4) | 3 (0.3) |
Data are presented as mean (standard error of the mean) or median (interquartile range) for continuous variables and as n (%) for categorical variables. COPD indicates chronic obstructive pulmonary disease; CRT, cardiac resynchronization therapy; eGFR, estimated glomerular filtration rate; ICD, implantable cardioverter defibrillator; LVEF, left ventricular ejection fraction; MRA, mineralocorticoid receptor antagonist; NYHA, New York Heart Association; WCC, white cell count.
a
Sepsis vs nonsepsis death, P<0.05.
b
All‐cause death vs survivors, P<0.05.