Table 2.
Predictors of Sepsis Death
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Age (per y) | 1.05 (1.04‐1.07) | <0.001 | 1.05 (1.03‐1.07) | <0.001 |
| Male sex | 1.20 (0.84‐1.72) | 0.31 | 1.73 (1.16‐2.60) | 0.008 |
| Diabetes mellitus | 1.09 (0.79‐1.52) | 0.6 | 0.91 (0.63‐1.31) | 0.611 |
| COPD | 3.07 (2.24‐4.20) | <0.001 | 2.43 (1.74‐3.40) | <0.001 |
| Ischemic etiology | 1.20 (0.88‐1.63) | 0.258 | 0.78 (0.55‐1.11) | 0.172 |
| NYHA class (vs 1) | <0.001 | 0.079 | ||
| 2 | 2.27 (1.30‐3.98) | 1.66 (0.92‐3.00) | ||
| 3 | 3.71 (2.12‐6.52) | 2.18 (1.17‐4.07) | ||
| 4 | 3.32 (0.92‐12.03) | 1.54 (0.39‐6.05) | ||
| Heart rate (per bpm) | 1.01 (1.00‐1.01) | 0.167 | 1.00 (1.00‐1.01) | 0.347 |
| QRS interval (per ms) | 1.00 (1.00‐1.01) | 0.062 | 1.00 (1.00‐1.01) | 0.333 |
| Hemoglobin (per g/dL) | 0.82 (0.75‐0.90) | <0.001 | 0.90 (0.80‐1.00) | 0.052 |
| WCC (per 109/L) | 1.03 (0.99‐1.06) | 0.174 | ··· | ··· |
| Lymphocytes (per 109/L) | 0.85 (0.60‐1.21) | 0.372 | 1.13 (0.82‐1.58) | 0.452 |
| Neutrophils (per 109/L) | 1.06 (1.01‐1.12) | 0.018 | 0.99 (0.93‐1.06) | 0.784 |
| Platelets (per 109/L) | 1.002 (1.00‐1.004) | 0.12 | 1.002 (1.000‐1.005) | 0.027 |
| Sodium (per mmol/L) | 0.96 (0.92‐1.00) | 0.043 | 0.98 (0.94‐1.03) | 0.383 |
| eGFR (per mL/[kg·min]) | 0.98 (0.98‐0.99) | <0.001 | 0.99 (0.98‐1.00) | 0.248 |
| Albumin (per g/L) | 0.94 (0.91‐0.97) | <0.001 | 0.99 (0.95‐1.03) | 0.531 |
| Vitamin D (per 2.82‐fold increase) | 0.65 (0.48‐0.89) | 0.008 | 0.68 (0.49‐0.95) | 0.022 |
| LVEF (per %) | 1.000.99‐1.02) | 0.691 | 1.00 (0.98‐1.02) | 0.921 |
| Diuretic dose (per mg/d) | 1.003 (1.001‐1.005) | 0.005 | 1.00 (1.00‐1.00) | 0.886 |
CI indicates confidence interval; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; HR, hazard ratio; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; WCC, white cell count.