Dynamic changes during exercise in healthy controls, TGA‐Mustard/Senning patients, and ccTGA patients. To assess differences in the response of TGA‐Mustard/Senning (blue) vs ccTGA patients (red), a P for interaction was calculated. The systemic RV of patients was compared with the systemic LV of healthy controls (green). At each exercise intensity, *indicates a significant difference between healthy controls and TGA‐Mustard/Senning patients, †indicates a significant difference between healthy controls and ccTGA patients, and ‡indicates a significant difference between TGA‐Mustard/Senning and ccTGA patients. Error bars depict the standard error of the mean. bpm indicates beats per minute; CI, cardiac index; HR, heart rate; Pmax, maximal power output in watts; SBP, systolic blood pressure; sRVEDVi, systemic right ventricular end‐diastolic volume index; sRVESPVR, sRV end‐systolic pressure/volume relationship; SVi, stroke volume index; TGA, transposition of the great arteries.