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. 2018 Oct 4;7(20):e010013. doi: 10.1161/JAHA.118.010013

Figure 5.

Figure 5

Fibrotic gene expression and TGF‐β signaling in mutant αB‐crystallin (CryABR 120G) mice. A, PCR array results of upregulated fibrogenic transcripts in ventricles from 3‐month‐old nontransgenic (Ntg) and CryABR 120G mice (n=3). Complete quantitative data are shown in Table 1. B and C, Expression of a downstream target of TGF‐β signaling, phospho‐SMAD3 (p‐SMAD3) from 3‐month‐old Ntg and CryABR 120G hearts. D and E, Expression of a downstream target of noncanonical TGF‐β signaling, p‐TAK1. The Student unpaired t test was used to compare groups (n=6). *P<0.05 vs Ntg control; **P<0.001 vs Ntg control. ECM indicates extracellular matrix; GAPDH, glyceraldehyde 3‐phosphate; SMAD3, small mothers against decapentaplegic homolog 3; TAK1, transforming growth factor beta–activated kinase 1; TGF‐β, transforming growth factor beta.