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. 2018 Oct 4;7(20):e010013. doi: 10.1161/JAHA.118.010013

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fibrosis in myofibroblast specific transforming growth factor β receptor II gene (Tgfbr2) (r2)–ablated mutant αB‐crystallin (CryAB^R ^120G) mice. A, Masson's trichrome and Sirius Red staining of left ventricle sections from 20‐week‐old Cry AB^R ^120G /Postnmcm/Tgfbr2 ^f/f (r2) fed with TAM chow (TAM+) or normal chow (−). B, Quantification of fibrosis from the images obtained from Sirius Red–stained sections (n=4–5). C, Hydroxyproline in hearts derived from nontransgenic (Ntg), Cry AB^R ^120G /Postnmcm, Cry AB^R ^120G /r2 ^f/f , Postnmcm/r2 ^f/f and Cry AB^R ^120G /Postnmcm/r2 ^f/f fed with TAM+ or normal chow (−) as in (A) and aged for 5 months (n=5–6), *P<0.05 vs TAM+ Cry AB^R ^120G /Postnmcm/r2 ^f/f; **P<0.001 vs TAM+ Cry AB^R ^120G /Postnmcm/r2 ^f/f.