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. 2018 Oct 4;7(20):e010013. doi: 10.1161/JAHA.118.010013

Figure 14.

Figure 14

Ablation of transforming growth factor β receptor II gene Tgfbr2 (r2) in myofibroblasts preserves cardiac function and improves survival in mutant αB‐crystallin (CryABR 120G) mice. A, Left ventricular (LV) mass. B, Fractional shortening (FS) and C, Left atrial (LA) dimension and D, Ventricular filling velocity (MV E/A; n=6–9). All measurements were performed at 5 months. *P<0.05, vs tamoxifen (TAM)+ Cry ABR 120G /Postnmcm/r2 f/f in pair‐wise comparisons between the indicated groups using 1‐way ANOVA followed by Tukey's post hoc test. NS indicates not significant. E, Kaplan–Meier survival curves of the CryABR 120G mice with and without myofibroblast Tgfbr2 ablation. n=10 to 12. *P<0.05, vs comparisons between the curves using the log‐rank test. Ntg indicates nontransgenic.