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. Author manuscript; available in PMC: 2019 Apr 20.
Published in final edited form as: Nature. 2018 May 30;558(7709):318–323. doi: 10.1038/s41586-018-0174-3

Extended Data Fig. 9 |. A model depicting how P-TEFb uses the CYCT1 HRD to target and recruit the Pol II CTD into a phase-separated compartment—which is formed by weak, multivalent homotypic interactions among the HRDs—to enable highly efficient phosphorylation of CTD by P-TEFb in the presence of ATP.

Extended Data Fig. 9 |

At 2.5% 1,6-hexanediol, the HRD-mediated phase separation but not the direct HRD–CTD binding is disrupted, making it impossible for P-TEFb to hyperphosphorylate the CTD.