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. Author manuscript; available in PMC: 2020 Jan 24.
Published in final edited form as: Cell. 2019 Jan 10;176(3):468–478.e11. doi: 10.1016/j.cell.2018.12.005

Figure 1: DEER Distance Measurements of the AT1R.

Figure 1:

(A) Site-directed spin labeling of AT1R intracellular regions with the nitroxide-containing V1 side chain allows the detection of ligand-dependent conformational changes by DEER spectroscopy, as shown schematically for TMs 1 and 6.

(B) AT1R labeling strategy indicating six labeling sites and their ten pairwise combinations (dotted lines), shown on the crystal structure of AT1R bound to the candesartan precursor ZD7155 (PDB: 4YAY).

See also Figure S1 and Table S2.