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. Author manuscript; available in PMC: 2019 Sep 21.
Published in final edited form as: ACS Chem Biol. 2018 Aug 30;13(9):2794–2807. doi: 10.1021/acschembio.8b00729

Table 1.

List of Investigated Anti-SOD1 Antibodies and Their Expected Specificities

antibody raised in antigen type expected reactivity/specificity
Ab16831 (Abcam) rabbit total human WT SOD1 pAba total SOD1
2770 (Cell Signaling Technology) rabbit human SOD1 N-terminal epitope pAb total SOD1
B8H10 (MédiMabs) mouse human G93A SOD1 mAba misfolded SOD1
C4F6 (MédiMabs) mouse human G93A SOD1 mAb misfolded SOD1
AMF7–63 rabbit the electrostatic loop D125DLGKGGNEESTKTGNAG142 mAb high affinity for misfolded SOD1
3H1 mouse the electrostatic loop D125DLGKGGNEESTKTGNAG142 mAb 1000-fold lower affinity than AMF7–63
10C12 mouse SOD1-exposed dimer interface (SEDI)13 with Cys146 replaced by cysteic acid mAb oxidized misfolded SOD1 monomers/oligomers/aggregates
a

mAb = monoclonal antibody. pAb = polyclonal antibody.