Table 2.
Laboratory parameters by depression status in chronic hepatitis B patients.
| Variables | Depressive symptoms | p | ||
|---|---|---|---|---|
| None (N=148) | Subclinical (N=50) | Clinical (N=11) | ||
| ALT (U/L) | 124.2±144.8 | 185.6±234.2 | 257.9±121.3* | 0.008 |
| AST (U/L) | 81.9±108.7 | 138.0±216.6* | 199.2±76.3* | 0.004 |
| HBV-DNA (IU/mL) | 4.6E8±2.4E8 | 2.3E8±6.1E8 | 5.2E7±1.3E8 | 0.701 |
| HBeAg positive | 91 (61.5%) | 32 (64.0%) | 9 (81.8%) | 0.399 |
| TBil (μmol/L) | 24.4±26.0 | 49.8±76.3* | 80.9±47.1* | 0.000 |
| FT3 (pmol/L) | 4.6±1.0 | 4.1±1.0* | 3.5±0.9* | 0.000 |
| FT4 (pmol/L) | 14.4±2.2 | 14.6±2.7 | 15.0±2.3 | 0.858 |
| Low FT3 (<3.5 μmol/L) | 14 (9.5%) | 15 (30.0%)* | 6 (50.0%)* | 0.000 |
| TSH (μIU/mL) | 2.0±1.9 | 2.1±2.2 | 2.0±0.6 | 0.970 |
| TSH reduction (<0.55 mIU/L) | 4 (2.0%) | 5 (8.0%) | 0 (0.0%) | 0.071 |
| TSH rise (>4.78 mIU/L) | 4 (2.7%) | 4 (8.0%) | 0 (0.0%) | 0.197 |
*
P<0.05 vs. none.
ALT – alanine aminotransferase; AST – aspartate aminotransferase; HBeAg – hepatitis B e-antigen; TBil – total bilirubin; TSH – thyroid stimulating hormone.