Table 4.
Laboratory parameters by insomnia status in chronic hepatitis B patients.
| Variables | Insomnia symptoms | p | ||
|---|---|---|---|---|
| None (N=112) | Subclinical (N=23) | Clinical (N=74) | ||
| ALT (U/L) | 114.9±126.4 | 194.4±222.5 | 177.8±206.1* | 0.018 |
| AST (U/L) | 69.4±72.4 | 103.5±104.1 | 149.5±209.9* | 0.001 |
| HBV-DNA (IU/mL) | 5.9E8±2.8E8 | 2.3E8±6.0E8 | 1.4E8±4.3E8 | 0.338 |
| HBeAg positive | 67 (59.8%) | 12 (52.2%) | 53 (71.6%) | 0.135 |
| TBil (μmol/L) | 22.3±22.6 | 34.7±43.6 | 50.0±65.0* | 0.000 |
| FT3 (pmol/L) | 4.7±1.0 | 4.5±0.9 | 4.0±1.0* | 0.000 |
| FT4 (pmol/L) | 14.4±2.2 | 14.6±2.7 | 15.0±2.3 | 0.858 |
| Low FT3 (<3.5 μmol/L) | 7 (6.3%) | 4 (17.4%) | 24 (32.4%)* | 0.000 |
| TSH (μIU/mL) | 2.1±2.1 | 2.0±1.0 | 2.0±1.9 | 0.995 |
| TSH reduction (<0.55 mIU/L) | 3 (2.7%) | 2 (8.7%) | 4 (5.4%) | 0.366 |
| TSH rise (>4.78 mIU/L) | 3 (2.7%) | 3 (13.0%) | 3 (4.1%) | 0.082 |
*
P<0.05 vs. none.
ALT – alanine aminotransferase; AST – aspartate aminotransferase; HBV-DNA – hepatitis B virus-deoxyribonucleic acid; HBeAg – hepatitis B e-antigen; TBil – total bilirubin; TSH – thyroid stimulating hormone.