Table 3.
Conclusions, the number of MAs, average CC/CO/CS studies and patients and average AMSTAR score about the association between OH and other diseases
| Conclusions | No of included MAs | Average CC/CO/CS studies included | Average patients included | Average AMSTAR score |
| Plasma homocysteine levels were found to be significantly higher in patients with OH58 | 1 | 2/3/0 | 586 | 10 |
| There is a significant association between OH and tunnel syndrome49 | 1 | 3/1/0 | 71 133 | 7 |
| OH is significantly associated with increased all-cause mortality in patients with HF43 | 1 | 0/10/0 | 19 354 | 10 |
| OH is significantly associated with increased cardiac death and/or hospitalisation in patients with HF43 | 1 | 0/10/0 | 21 858 | 10 |
| OH is significantly associated with a risk factor for gestational diabetes37 | 1 | 0/3/0 | 225 427 | 7 |
| OH is significantly associated with the severity of obstructive sleep apnea57 | 1 | 0/8/4 | 1615 | 7 |
| OH is significantly associated with breast cancer39 | 1 | 1/2/3 | 6175 | 6 |
| Maternal OH is significantly associated with the occurrence of preterm birth40 41 48 74 | 4 | 0.25/7.5/0.25 | 1 152 475 | 8.75 |
| Mothers with hypothyroidism during pregnancy have a significant increased tendency to give birth to children with higher birth weight40 | 1 | 0/9/0 | 1 627 521 | 8 |
| Mothers with hypothyroidism during pregnancy have a significant increased tendency to give birth to children with lower birth weight40 | 1 | 0/5/0 | 23 879 | 8 |
| Maternal OH shows a significant trend of reduced risk of large for gestational age40 | 1 | 0/3/0 | 1 612 705 | 8 |
| No evidence shows a significant relationship between maternal OH and small for gestational age40 | 1 | 0/4/0 | 1 613 846 | 8 |
| Hypothyroidism has an increased risk of developing glaucoma68 | 1 | 2/5/4 | 381 695 | 9 |
| There seems to be an association between hypothyroidism and glaucoma69 | 1 | 4/2/7 | 173 763 | 9 |
| Hypothyroidism is a risk factor for CHD and cardiac mortality70 | 1 | 0/13/0 | 615 596 | 9 |
| No significant association between NAFLD and OH72 | 1 | 1/1/4 | 27 070 | 10 |
| OH is at higher risk for NAFLD than euthyroid subjects73 | 1 | 4/2/4 | 42 143 | 10 |
| Hypothyroidism is not related to the risk for breast cancer65 | 1 | 12/0/0 | 24 571 | 9 |
AMSTAR, Assessment of Multiple Systematic Reviews; CC/CO/CS; case–control/cohort/cross-sectional; CHD, coronary heart disease; HF, heart failure; MAs, meta-analyses; NAFLD, non-alcoholic fatty liver disease; OH, overt hypothyroidism.