Table 5.
Association between SCH/OH and other diseases (showed by RR/HR/OR)
| Author and year | Diseases | Sample size | No of included CC/CO/CS studies | RR/HR | OR | AMSTAR score |
| Subclinical hypothyroidism | ||||||
| Yan et al (2016)54 | Fractures | 314 146 | 0/5/0 | 1.20 (0.70, 2.04) | 9 | |
| Han et al (2015)38 | DN | 4761 | 7/0/3 | 1.35 (1.26, 1.44)* | 1.74 (1.34, 2.28) | 10 |
| DR | 4572 | 9/0/1 | 1.08 (0.99, 1.18)* | 1.42 (1.21, 1.67) | ||
| PAD | 801 | 4/0/0 | 1.33 (1.10, 1.60)* | 1.85 (1.35, 2.54) | ||
| CHD | 1896 | 7/0/0 | 1.29 (1.09, 1.52)* | 1.59 (0.92, 2.76) | ||
| DPN | 1710 | 3/0/0 | 2.27 (1.98, 2.60)* | 1.87 (1.06, 3.28) | ||
| Rodondi et al (2010)28 | CHD | 25 977 | 0/7/0 | 1.26 (1.16, 1.38)* | 1.33 (1.19, 1.49)* | 9 |
| CHD mortality | 54 301 | 0/10/0 | 1.63 (1.42, 1.87)* | 1.67 (1.45, 1.94)* | ||
| Total mortality | 55 287 | 0/11/0 | 1.57 (1.48, 1.67)* | 1.78 (1.64, 1.92)* | ||
| Ning et al (2015)43 | All-cause mortality of heart failure patients | 19 354 | 0/10/0 | 1.44 (1.29, 1.61) | 10 | |
| Cardiac death and/or hospitalisation of heart failure patients | 21 858 | 0/10/0 | 1.37 (1.22, 1.55) | |||
| Rieben et al (2016)47 | Dementia | 7401 | 0/6/0 | 1.14 (0.84, 1.55) | 1.08 (0.78, 1.51)* | 10 |
| Eftekharzadeh et al (2016)34 | Metabolic syndrome | 34 517 | 1/1/7 | 1.13 (0.95, 1.34) | 10 | |
| Chaker et al (2014)32 | Stroke | 10 118 | 0/5/0 | 1.08 (0.87, 1.34)† | 10 | |
| Zhou et al (2016)78 | CKD in diabetes patients | 38 284 | 4/0/2 | 1.81 (1.43, 2.29) | 6 | |
| Hou et al (2016)40 | Low birth weight | 23 879 | 0/5/0 | 1.31 (1.00, 1.72) | 1.11 (0.84, 1.48)* | 8 |
| SGA | 1 613 846 | 0/4/0 | 1.02 (0.87, 1.19) | |||
| LGA | 1 612 705 | 0/3/0 | 1.17 (0.99, 1.38) | 0.99 (0.84, 1.17)* | ||
| Li et al (2016)41 | Preterm birth | 455 716 | 0/14/1 | 1.17 (1.07, 1.28)* | 1.25 (1.04, 1.51) | 10 |
| Tong et al (2016)51 | IGR | 16 157 | 0/7/0 | 2.05 (1.43, 2.94)* | 1.54 (1.06, 2.25) | 8 |
| Gong et al (2016)37 | Gestational diabetes | 225 427 | 0/3/0 | 1.89 (1.70, 2.11)* | 1.558 (1.292, 1.877) | 7 |
| Thompson et al (2018)61 | Intelligence development of the offspring | 909 176 | 0/37/0 | 2.14 (1.20, 3.83) | 10 | |
| Zhou et al (2017)62 | Diabetic nephropathy | 545 | 5/0/0 | 1.8 (1.38, 2.35) | 7 | |
| Sun et al (2017)63 | CHD5 | 4979 | 0/10/0 | 1.17 (0.91, 1.52) | 10 | |
| Liu et al (2018)64 | Fetal growth restriction | 8958 | 0/3/0 | 2.4 (1.56, 3.7) | 9 | |
| Zhang et al (2017)67 | Premature delivery miscarriage | 6036 | 0/3/0 | 1.45 (1.07, 1.96) | 9 | |
| Nasirkandy et al (2017)71 | Preterm birth | 68 465 | 0/17/0 | 1.36 (1.09, 1.68) | 9 | |
| Xu et al (2017)79 | Fracture | 289 575 | 0/6/0 | 1.22 (0.61, 2.47） | 7 | |
| Overt hypothyroidism | ||||||
| Shiri (2014)49 | Carpal tunnel syndrome | 71 133 | 3/1/0 | 1.44 (1.27, 1.63) | 7 | |
| Gong et al (2016)37 | Gestational diabetes | 63 567 | 0/6/0 | 1.57 (1.28, 1.93)* | 1.62 (1.30, 2.01)* | 7 |
| Fang et al (2017)65 | Breast cancer | 24 571 | 12/0/0 | 0.83 (0.64, 1.08) | 9 | |
| Wang et al (2017)68 | Glaucoma | 381 695 | 2/5/4 | 1.64 (1.27, 2.13) | 9 | |
| Ning et al (2017)70 | Cardiovascular | 615 596 | 0/13/0 | 1.13 (1.01, 1.26) | 9 | |
| Nasirkandy et al (2017)71 | Preterm birth | 2 472 896 | 0/10/0 | 1.3 (1.05, 1.61) | 9 | |
| He et al (2017)73 | NAFLD | 42 143 | 4/2/4 | 1.52 (1.24, 1.87) | 10 | |
*The RR or OR calculated according to the sample size.
**†HR.
AMSTAR, Assessment of Multiple Systematic Reviews; CC /CO /CS, case–control/cohort/cross-sectional; CHD, coronary heart disease; CKD, chronic kidney diseases; DPN, diabetic peripheral neuropathy; DN, diabetic nephropathy; DR, diabetic retinopathy; HR, hazard ratio; IGR, intrauterine growth restriction; LGA, large for gestational age; NAFLD, non- alcoholic fatty liver disease; PAD, peripheral arterial disease; RR, relative ratio; SGA, small for gestational age.