Table 6.
Association between SCH/OH and other diseases (showed by WMD/SMD)
| Author and year | Diseases | Sample size | No of included CC/CO/CS studies | WMD/SMD (95% CI) | AMSTAR score |
| Subclinical hypothyroidism | |||||
| Ye et al (2014)56 | SBP | 50 147 | 0/6/14 | 1.47 mm Hg (0.54 to 2.39 mm Hg), p=0.002 | 8 |
| DBP | 48 636 | 0/5/14 | 0.44 mm Hg (–0.15 to 1.02 mm Hg), p=0.142 | ||
| Liu et al (2014)42 | TC level | 40 546 | 3/0/13 | 12.17 mg/dL (7.79 to 16.54 mg/dL), p<0.001 | 10 |
| LDL-C level | 39 131 | 3/0/12 | 7.01 mg/dL (3.95 to 10.06 mg/dL), p<0.001 | ||
| HDL-C level | 40 559 | 3/0/13 | −0.50 mg/dL (−1.90 to 0.89 mg/dL), p=0.481 | ||
| TG level | 40 420 | 3/0/11 | 13.19 mg/dL (4.92 to 21.46 mg/dL), p<0.001 | ||
| Zhou et al (2014)58 | Plasma homocysteine status | 926 | 0/8/0 | 0.07 (−0.10 to 0.24), p=0.425* | 10 |
| Wang et al (2013)75 | C-IMT | 4551 | 0/0/9 | 0.05 mm (0.02 to 0.07 mm), p=0.000 | 9 |
| Rieben et al (2016)47 | MMSE | 16 805 | 0/11/0 | ES, 0.01 points difference from baseline (−0.10 to 0.12) | 10 |
| Aziz et al (2017)66 | C-IMT | 543 | 9 clinical trials | 0.44 mm Hg (0.14 to 0.74), p=0.004 | 10 |
| Overt hypothyroidism | |||||
| Zhang et al (2016)57 | AHI | 1389 | 0/3/2 | 0.41 (0.21 to 0.61), p<0.001* | 5 |
| Desat time | 1414 | 0/4/2 | 0.32 (0.12 to 0.51), p<0.01* | ||
| ESS | 1383 | 0/3/2 | 2.12 (0.89 to 3.35), p<0.001* | ||
| RDI | 204 | 0/3/0 | −2.17 (−11.80 to 7.46), p=0.66* | ||
| Sleeping efficiency | 444 | 0/3/0 | −1.60 (−5.57 to 2.37), p=0.43* | ||
| Time of sleep with oxygen desaturation under 90% | 1416 | 0/4/2 | 0.32 (0.12 to 0.51), p=0.001 | ||
| Zhou et al (2014)58 | Plasma homocysteine status | 586 | 2/3/0 | 0.67 (0.40 to 0.94), p=0.000* | 10 |
*SMD.
AHI, Apnoea–Hypopnoea Index; AMSTAR, Assessment of Multiple Systematic Reviews; CCs/COs/CSs, case–control/cohort/cross-sectional studies; C-IMT, carotid intima-media thickness; DBP, diastolic blood pressure; ESS, Epworth Sleepiness Scale; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; MMSE, Mini Mental State Examination; OH, overt hypothyroidism; RDI, Respiratory Disturbance Index; SBP, systolic blood pressure; SCH, subclinical hypothyroidism; SMD, standardised mean difference; TC, total cholesterol; TG, total triglyceride; WMD, weighted mean difference; ES, Expected Shortfall