Table 2.
Summary of single cut and allograft axonal morphometric data at 7-42d PO.
| Treatment | SFI | Mean axon diameter (μm) |
Mean g ratio |
Axons/10,000 μm2 |
MFA (μm2) |
MFI (%) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| prox | graft | distal | prox | graft | distal | prox | graft | distal | ||||
| Unoperated | ||||||||||||
| Unoperated mean | −4 | 3.95 | [3.88] | 3.82 | 0.62 | [0.62] | 0.61 | 210 | [201] | 191 | 2710 | 100% |
| 7d PO (7-14d PO) | ||||||||||||
| PEG mean | −78 (−90) | 3.88 | 3.41 (2.69) | 0.67 | 0.64 (0.66) | 154 | 226 (196) | 71% (80%) | ||||
| NC mean | −85 (−98) | 0 | 0 (0) | 0 | 0 (0) | 0 | 0 (0) | 1370 | 0% (0%) | |||
| 21d PO | ||||||||||||
| PEG mean | −64 (70) | 3.56 | 2.62 | 2.01 (3.24) | 0.62 | 0.71 | 0.62 (0.71) | 192 | 307 | 448 (150) | 620 | 91% (78%) |
| NC mean | −90 (−87) | 2.7 | 2.24 | 1.35 (1.72) | 0.73 | 0.8 | 0.78 (0.76) | 150 | 18 | 3 (116) | 0% (0%) | |
| 42d PO | ||||||||||||
| PEG mean | −8, (−22) | 3.33 (3.82) | 2.87 | 2.96 (2.98) | 0.64 (0.64) | 0.65 | 0.67 (0.68) | 198 (190) | 264 | 236 (218) | 2890 (1780) | 99% (98%) |
| NC mean | −106, (−83) | 3.27 (3.37) | 2.07 | 1.59 (1.90) | 0.64 (0.66) | 0.72 | 0.63 (0.65) | 175 (199) | 160 | 151 (237) | 790 (1440) | 8% |
Table 2 lists mean allograft ablation data (black font) versus single cut data (red font) for sciatic nerve lesions in the mid-thigh for each protocol and PO times, as given in the 1st column. N= 2-6 nerves sampled for each mean. These protocols are: Unoperated (Unop), PEG-fused (PEG: yellow highlighted) and Negative Control (NC). Each PO time is 7-14d, 21d, or 42d. For each protocol at each PO time Table 1 lists in sequential columns: SFI scores, axon diameter (μm), g ratio (axon diameter/fiber diameter), axon density (per 10,000μm2), average fiber diameter and the average of the ten largest fibers (MAX10), muscle fiber cross sectional area (MFA), and % of muscle fibers having innervated muscle fibers (MFI%).