. 2019 Mar 23;9(3):e024324. doi: 10.1136/bmjopen-2018-024324

Table 4.

Antibiotic uptake, optimal and suboptimal delivery, anaphylaxis

Parameter	Input data	Data source
Uptake of antibiotics
Maternal infection at term	80%	Expert group consensus agreement
Maternal infection at pre-term	85%	Expert group consensus agreement
Pre-term pre-labour rupture of membranes (pPROM)	5%	Expert group consensus agreement
Screened group B Streptococcus (GBS) positive	80% [Sensitivity analysis 70%–90%]	Expert group consensus agreement [based on Albouy-Llaty et al. 2012⁴⁶]
Previous baby with early onset GBS (EOGBS)	90%	Expert group consensus agreement
Incidental detection of GBS carriage	47%	Moorthy et al, 2014⁴⁷
Optimal and suboptimal intrapartum antibiotic prophylaxis (IAP) delivery

Parameter	Optimal IAP (delivered >2 hours)	Suboptimal IAP (delivered <2 hours)	Data source
Groups treated with antibiotics not solely for prevention of EOGBS
Maternal infection at term	20%	80%	Expert group consensus agreement
Maternal infection at pre-term	10%	90%	Expert group consensus agreement
pPROM	65%	35%	Expert group consensus agreement
Groups receiving IAP solely for the prevention of EOGBS
Screened GBS positive	65%	35%	Expert group consensus agreement [based on Lin et al., 2011³⁰]
Previous baby with EOGBS	65%	35%	Expert group consensus agreement
Incidental detection of GBS carriage	65%	35%	Expert group consensus agreement
IAP effectiveness in preventing EOGBS
IAP effectiveness (prevention of EOGBS)	RR^* 0.17 (Sensitivity analysis 0.05 to 0.30) RR=relative risk	RR^* 0.58 (Sensitivity analysis 0.525 to 0.65) Suboptimal effectiveness is 50% lower than optimal	Ohlsson et al, 2014²⁹ (optimal) and expert group consensus agreement (sub-optimal)
Allergy, resistance and anaphylaxis rates
Self-reported penicillin allergy rate	8%		Turrentine et al, 2009⁴⁸ and Zilberman et al, 2014⁴⁹
Clindamycin resistance rate	17%		Public Health England, 2014 (2013 data)⁵⁰
Maternal penicillin anaphylaxis	1.56 per 100 000 women treated		Mulla et al, 2010⁵¹