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. 2019 Mar 29;116(16):7926–7931. doi: 10.1073/pnas.1820892116

Fig. 2.

Fig. 2.

LNP023 blocks KRN-induced arthritis. Arthritis was induced by KRN/I-Ag7 serum transfer in C57BL/6 mice 1 h after the first dose of compound (n = 8 mice per dose group). (A) Disease score was measured by joint swelling and shown as mean ± SEM. (B) Levels of complement activation products Ba, C3d, and C5a in the joint. (C) Representative images of joint histological analysis (H&E stain) and evaluation of inflammatory cell infiltration, bone erosion, and proteoglycan (PG) loss (safranin O staining) after 6 d of treatment. Vehicle (black bars), 20 mg/kg b.i.d. (light blue bars), 60 mg/kg b.i.d. (medium blue bars), and 180 mg/kg b.i.d. (dark blue bars). Data are mean ± SEM. P values were calculated using one-way ANOVA followed by Dunnett’s multiple comparison test with a single pooled variance (for complement activation fragments and histology) or repeat measure two-way ANOVA followed by Dunnett’s multiple comparison test; **P < 0.01, ***P < 0.001, ****P < 0.0001. (Scale bars, 400 µm.)