Fig. 6.

Comparison of current (network) and previous (cell group-based) models of hypothalamic organization. An established cell group-based model of hypothalamic organization (Lower half of flatmap) divides it into four transverse levels (preoptic, anterior/supraoptic, tuberal, mammillary) and three longitudinal zones (periventricular, medial, lateral). Refinements to this model include the identification of a neuroendocrine motor zone (gray), medial zone nuclei (red) considered to form the rostral end of a behavior control column, and a periventricular region (pink) containing a putative visceromotor network (green), leaving the remaining lateral zone (yellow) (11, 35). The Upper half of the flatmap shows the two top-level partitions of the bilateral hypothalamus macroscale subconnectome (HY2). For comparison, each organization schema is presented on a single side. Most HY2 subsystem 1.1 regions (lighter blue) are in the periventricular zone and include all regions of the neuroendocrine motor zone and a putative visceromotor network, whereas most HY2 subsystem 1.2 regions (darker blue) are in the lateral and medial zones. The hypothalamus (magenta) and its spatial relation to the CNS is represented on the gray flatmap at Lower Left.