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View full-text article in PMC

. 2019 Apr 1;116(16):8010–8017. doi: 10.1073/pnas.1821844116

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Fig. 1. — Pejvakin promotes pexophagy in response to sound in auditory hair cells. (A) Changes in peroxisome number in P21 Pjvk^+/+ IHCs (n = 60; four mice per time point) after sound exposure (5–40 kHz, 105 dB SPL, 1 h). The arrows indicate the sound stimulation period (1 h). (B) Impaired early elimination and proliferation of peroxisomes in Pjvk^−/− IHCs in response to sound (n = 60 IHCs; four mice per time point). (C) LC3B-mediated pexophagy is altered in Pjvk^−/− IHCs. The number of coimmunolabeled LC3B/PMP70 spots increased at 1 h after sound exposure in Pjvk^+/+ IHCs, but not in Pjvk^−/− IHCs. (D) The number of LC3B/pejvakin PLA spots (in red) was higher at 1 h after sound exposure in Pjvk^+/+ IHCs. No LC3B/pejvakin PLA spots were observed in Pjvk^−/− IHCs. The bar charts quantify LC3B/PMP70 coimmunolocalization in IHCs from Pjvk^+/+ and Pjvk^−/− mice (C) and LC3B/pejvakin PLA spots in Pjvk^+/+ and Pjvk^−/− IHCs (D) before and at 1 h after sound exposure (n = 40 IHCs; four mice per genotype and condition). Data are mean ± SEM. ***P < 0.001; n.s., not significant, unpaired Student’s t test. (Scale bars: 5 μm.)