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. 2019 Mar 20;9(3):e023614. doi: 10.1136/bmjopen-2018-023614

Table 4.

Relative risks (RRs) of autoimmune diseases in subjects with myocardial infarction (MI) in first-degree relatives

Autoimmune diseases Sex Subjects with MI in first-degree relatives General population RR (95% CI)*
No. Prevalence, % No. Prevalence, %
Congenital hypothyroidism Male 27 0.02 4347 0.04 0.95 (0.65 to 1.38)
Female 54 0.05 6575 0.05 0.90 (0.69 to 1.18)
All 81 0.03 10 922 0.04 0.89 (0.71 to 1.10)
Rheumatoid arthritis Male 114 0.08 11 163 0.09 0.83 (0.69 to 1.00)
Female 284 0.26 44 686 0.36 0.85 (0.76 to 0.96)
All 398 0.15 55 849 0.23 0.84 (0.76 to 0.92)
Sjögren’s syndrome Male 32 0.02 2359 0.02 1.01 (0.70 to 1.46)
Female 242 0.22 19 315 0.16 1.08 (0.94 to 1.26)
All 274 0.11 21 674 0.09 1.06 (0.93 to 1.21)
Systemic lupus erythematosus Male 28 0.02 2209 0.02 0.91 (0.64 to 1.29)
Female 178 0.16 20 552 0.17 1.18 (1.04 to 1.34)
All 206 0.08 22 761 0.09 1.14 (1.01 to 1.28)
Systemic sclerosis Male 7 0.00 461 0.00 1.06 (0.51 to 2.22)
Female 11 0.01 1615 0.01 0.88 (0.49 to 1.57)
All 18 0.01 2076 0.01 0.94 (0.59 to 1.48)
Polymyositis/dermatomyositis Male 9 0.01 646 0.01 0.98 (0.51 to 1.87)
Female 22 0.02 1472 0.01 1.74 (1.15 to 2.62)
All 31 0.01 2118 0.01 1.41 (1.00 to 2.00)
Behçet disease Male 7 0.00 883 0.01 0.53 (0.25 to 1.12)
Female 7 0.01 1186 0.01 0.58 (0.28 to 1.21)
All 14 0.01 2069 0.01 0.55 (0.32 to 0.92)
Vasculitis Male 23 0.02 3087 0.03 1.07 (0.71 to 1.60)
Female 10 0.01 1958 0.02 0.79 (0.43 to 1.47)
All 33 0.01 5045 0.02 0.95 (0.67 to 1.35)
Inflammatory bowel disease Male 32 0.02 1798 0.01 1.21 (0.86 to 1.70)
Female 5 0.00 1009 0.01 0.56 (0.23 to 1.34)
All 37 0.01 2807 0.01 1.05 (0.76 to 1.44)
Multiple sclerosis Male 0 0.00 354 0.00 0.18 (0.03 to 1.27)
Female 12 0.01 1234 0.01 0.97 (0.56 to 1.71)
All 13 0.01 1588 0.01 0.73 (0.42 to 1.25)
Myasthenia gravis Male 41 0.03 2820 0.02 1.11 (0.82 to 1.50)
Female 34 0.03 4312 0.04 0.87 (0.62 to 1.21)
All 75 0.03 7132 0.03 0.98 (0.78 to 1.23)
Type 1 diabetes mellitus Male 86 0.06 4884 0.04 0.96 (0.78 to 1.18)
Female 91 0.08 5841 0.05 0.99 (0.82 to 1.21)
All 177 0.07 10 725 0.04 0.98 (0.85 to 1.13)

*Adjusted for age, gender, place of residence, quintiles of income levels, occupation, family size and Charlson Comorbidity Index.