Table 2.
Glucocorticoid-related complication rates in patients with polymyalgia rheumatica (PMR) and comparators without PMR*
| Electronic coding, % |
No. of events§ |
Cumulative incidence (95% CI) |
|||||
|---|---|---|---|---|---|---|---|
| Complication | Agreement† | Excess events |
Before | After | At 5 years, PMR |
At 5 years, non-PMR |
HR (95% CI) |
| Diabetes mellitus | 81 | 18 | 93/104 | 38/39 | 9.5 (5.8–13.1) | 11.5 (7.3–15.5) | 0.85 (0.54–1.33) |
| Hypertension | 85 | 13 | 255/253 | 42/47 | 30.4 (20.2–39.2) | 33.4 (23.3–42.2) | 0.79 (0.52–1.21) |
| Hyperlipidemia | 78 | 21 | 276/268 | 28/30 | 24.0 (13.6–33.1) | 26.6 (16.6–35.4) | 1.03 (0.61–1.74) |
| Cataracts | 85 | 10 | 203/197 | 77/66 | 41.0 (32.1–48.7) | 27.3 (19.8–34.2) | 1.72 (1.23–2.41) |
| Hip or femoral neck fracture | 99 | 1 | NA | 21/25 | 3.9 (1.8–6.0) | 5.1 (2.7–7.4) | 0.80 (0.45–1.43) |
| Symptomatic vertebral fracture | 90 | 3 | NA | 22/17 | 3.9 (1.8–6.0) | 2.4 (0.7–4.0) | 1.27 (0.67–2.39) |
| Colles fracture | 99 | 3 | NA | 15/13 | 2.4 (0.7–4.0) | 2.5 (0.8–4.2) | 1.11 (0.53–2.33) |
| Any fracture | 90 | 4 | NA | 49/49 | 9.5 (5.8–13.1) | 11.5 (7.3–15.5) | 0.85 (0.54–1.33) |
95% CI = 95% confidence interval; HR = hazard ratio; NA = not applicable.
Agreement between electronic coding and manual abstraction.
Excess events by coding.
PMR incidence/non-PMR index date.