Table 2.

Critical appraisal of therapeutic studies.

Author	Year  of publication	Study  design	Number of  participants	Level of  evidence	Validity						Importance			Applicability
					Randomization	Allocation  concealment	Intention-to-treat	Blinding	Comparable  treatment	Similarity  treatment &  control	Clinical  importance	Statistical  significance∗	Precision of   Treatment  effect	Domain	Feasibility of   treatment	Benefit  overweighs  harm
Davidson et al. [5]	2015	RCT	38	2	+	?	+	?	+	+	?	?	+	-	-	+
Kim et al. [7]	2016	RCT	95	2	+	-	-	-	+	+	-	-	+	-	-	+
Bobrow et al. [8]	2016	RCT	1157	2	+	+	+	+	+	+	-	+	-	-	+	+
Varleta et al. [6]	2017	RCT	291	2	+	+	+	+	+	+	+	+	+	+	+	+
Contreras et al. [9]	2018	RCT	148	2	+	+	+	+	+	+	+	+	+	-	+	+

+ means present; - means absent; ? means unclear/not mentioned; ∗ means statistical significance at p<0.05.