Fig. 1.

The effect of Ca²⁺ binding on the structure of S100A12. The Ca²⁺-free protein (green and cyan) is shown on the left, and the Ca²⁺-bound state (magenta and orange) is shown on the right, superimposed on the Ca²⁺-free state. Note the change in position of helix 3 between the Ca²⁺-free and Ca²⁺-bound states. PDB ID: 2WCE and 2M9G