Table 3.
Diagnostic Accuracy of the Lateral Flow Urine Lipoarabinomannan Assay Compared With the Composite Reference Standard (Definite Plus Probable Tuberculosis)
| Patient Group | Sensitivity | Specificity | PPV, % (95% CI) | NPV, % (95% CI) | ||
|---|---|---|---|---|---|---|
| No./Total | % (95% CI) | No./Total | % (95% CI) | |||
| All patients | 84/137 | 61.3 (53.0–69.1) | 123/143 | 86.0 (79.4–90.8) | 80.8 (72.2–87.2) | 69.9 (62.7–76.2) |
| CD4 cell count | ||||||
| <50/μL | 57/83 | 68.7 (58.1–77.6) | 84/100 | 84.0 (75.6–89.9) | 78.1 (67.3–86.0) | 76.4 (67.6–83.3) |
| 50–100/μL | 15/30 | 50.0 (33.2–66.8) | 25/27 | 92.6 (76.6–97.9) | 88.2 (65.7–96.7) | 62.5 (47.0–75.8) |
| >100/μL to 200/μL | 12/24 | 50.0 (31.4–68.6) | 14/16 | 87.5 (64.0–96.5) | 85.7 (60.1–96.0) | 53.8 (35.5–71.2) |
Abbreviations: CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.