Table 3:
MSM model results for Oxidized-LDL (oxLDL) with 5 level AMD outcome (worse eye)
| Hazard Ratio and 95% Confidence Interval for MSM Transitions: | ||||||||
|---|---|---|---|---|---|---|---|---|
| Incidence of Any AMD | Progression of AMD | Incidence of Late AMD | Disappearance of AMD | Regression of AMD | Death | |||
| Factor | (10 to 20) | (20 to 30) | (30 to 40) | (40 to 50) | (20 to 10) | (30 to 20) | (40 to 30) | |
| oxLDL (per 10 U/L) | 1.03 (0.98–1.09) | 0.98 (0.93–1.04) | 0.98 (0.89–1.08) | 0.97 (0.86–1.09) | 0.99 (0.90–1.09) | 1.04 (0.90–1.19) | 0.67 (0.49–0.93) * | 1.00 (0.97–1.02) |
| Age (per 5 yr) | 1.54 (1.45–1.65) * | 1.36 (1.25–1.48) * | 1.29 (1.08–1.54) * | 1.30 (1.06–1.58) * | 1.07 (0.93–1.23) | 0.89 (0.73–1.07) | 2.71 (1.24–5.94) * | 1.75 (1.68–1.81) * |
| Sex (male) | 1.01 (0.80–1.26) | 0.81 (0.61–1.08) | 0.68 (0.40–1.16) | 1.27 (0.66–2.43) | 1.22 (0.78–1.89) | 0.69 (0.35–1.38) | 5.58 (0.83–37.7) | 1.42 (1.26–1.60) * |
| Gene risk: Mod vs Low** | 1.39 (1.09–1.78) * | 1.53 (1.13–2.06) * | 1.59 (0.92–2.75) | 1.65 (0.92–2.98) | 0.75 (0.42–1.31) | 0.48 (0.21–1.10) | 2.17 (0.45–10.4) | 1.00 (0.87–1.14) |
| Gene risk: High vs Low** | 1.51 (1.00–2.29) * | 1.97 (1.26–3.06) * | 1.84 (1.03–3.29) * | 3.28 (1.58–6.81) * | 0.54 (0.17–1.75) | 0.36 (0.08–1.68) | 0.18 (0.00–21.5) | 1.01 (0.81–1.27) |
| Visit | 0.93 (0.85–1.01) | 0.96 (0.86–1.07) | 1.04 (0.84–1.29) | 1.12 (0.87–1.44) | 1.46 (1.22–1.75) * | 1.10 (0.83–1.45) | 1.20 (0.52–2.73) | 0.91 (0.87–0.95) * |
| AMD: 20 vs 10 | 0.90 (0.61–1.31) | |||||||
| AMD: 30 vs 10 | 1.48 (1.17–1.87) * | |||||||
| AMD: 40 vs 10 | 0.36 (0.07–1.89) | |||||||
| AMD: 50 vs 10 | 1.19 (0.92–1.53) | |||||||
*
Significant association (95% Confidence Interval does not include 1).
**
Gene risk is defined as low (0–1 risk alleles), moderate (2 risk alleles) and high (3–4 risk alleles)