Appendix Table 7.
Descriptive statistics for depression stratified by years of enrollment
| All participants | ||||||
| 2005–2007 | 2008–2010 | 2011–2013 | ||||
| EFV | NVP | EFV | NVP | EFV | NVP | |
| Proportion of participants ever
with depression (%) |
14/68 (21%) | 90/251 (36%) | 10/32 (31%) | 26/103 (25%) | 37/205 (18%) | 9/35 (26%) |
| Proportion of person-visits
with depression (%) |
26/415 (6.3%) | 164/1536 (11%) | 24/212 (11%) | 51/640 (8.0%) | 55/895 (6.1%) | 13/156 (8.3%) |
| Events/PY | 7/74.5 | 99/362.5 | 5/34.8 | 32/161.5 | 37/320.7 | 11/74.4 |
| Crude IR (events/100 PY) | 9.4 | 27.3 | 14.4 | 19.8 | 0.11 | 0.15 |
| Crude IR difference* (95% CI) | −17.9 (−26.7, −9.1) | −5.4 (−19.8, 8.9) | −3.3 (−12.8, 6.2) | |||
| Crude IRR, (exact 95% CI) | 0.34 (0.13, 0.74) | 0.73 (0.22, 1.88) | 0.78 (0.39, 1.70) | |||
| Excluding participants with pre-ART depression | ||||||
| 2005–2007 | 2008–2010 | 2011–2013 | ||||
| EFV | NVP | EFV | NVP | EFV | NVP | |
| Proportion of participants ever
with depression (%) |
2/41 (4.9%) | 34/156 (22%) | 3/18 (17%) | 13/79 (16%) | 12/147 (8.2%) | 5/25 (20%) |
| Proportion of person-visits
with depression (%) |
3/248 (1.2%) | 57/981 (5.8%) | 8/124 (6.5%) | 22/490 (4.5%) | 13/642 (2.0%) | 7/115 (6.1%) |
| Events/PY | 1/46.0 | 36/256.0 | 2/22.1 | 14/131.6 | 12/245.1 | 7/56.6 |
| Crude IR (events/100 PY) | 2.2 | 14.1 | 9.0 | 10.6 | 4.9 | 12.4 |
| Crude IR difference (95% CI) | −11.9 (−18.2, −5.6) | −1.6 (−15.3, 12.1) | −7.5 (−17.0, 2.1) | |||
| Crude IRR, (exact 95% CI) | 0.15 (0.00, 0.92) | 0.85 (0.09, 3.70) | 0.40 (0.14, 1.19) | |||
*All incidence rate differences and incidence rate ratios are given as comparing use of efavirenz vs. use of nevirapine
EFV = efavirenz; NVP = nevirapine; PY = person-years; IR = incidence rate; IRR = incidence rate ratio; CI = confidence interval; ART = antiretroviral therapy