Appendix Table 8.

Descriptive statistics for suicidal ideation stratified by years of enrollment

All participants
	2005–2007		2008–2010		2011–2013
	EFV	NVP	EFV	NVP	EFV	NVP
Proportion of participants ever with suicidal ideation (%)	1/68 (1.5%)	31/251 (12%)	5/32 (16%)	15/103 (15%)	13/205 (6.3%)	1/35 (2.9%)
Proportion of person-visits with suicidal ideation (%)	1/415 (0.2%)	43/1536 (2.8%)	9/212 (4.2%)	18/640 (2.8%)	14/895 (1.6%)	1/156 (0.6%)
Events/PY	1/89.3	31/436.4	1/39.4	19/180.5	13/350.8	2/82.7
Crude IR (events/100 PY)	1.1	7.1	2.5	10.5	3.7	2.4
Crude IR difference* (95% CI)	−6.0 (−9.3, −2.7)		−8.0 (−14.9, −1.1)		1.3 (−2.6, 5.2)
Crude IRR, (exact 95% CI)	0.16 (0.00, 0.95)		0.24 (0.01, 1.51)		1.53 (0.35, 14.00)
Excluding participants with pre-ART suicidal ideation
	2005–2007		2008–2010		2011–2013
	EFV	NVP	EFV	NVP	EFV	NVP
Proportion of participants ever with suicidal ideation (%)	1/64 (1.6%)	21/232 (9.1%)	3/26 (12%)	13/98 (13%)	10/194 (5.2%)	1/33 (3.3%)
Proportion of person-visits with suicidal ideation (%)	1/387 (0.3%)	27/1436 (1.9%)	5/173 (2.9%)	13/611 (2.1%)	10/845 (1.2%)	1/148 (0.7%)
Events/PY	1/84.9	21/412.0	0/32.9	16/171.2	10/334.9	2/79.2
Crude IR (events/100 PY)	1.2	5.1	0.0	9.3	3.0	2.5
Crude IR difference (95% CI)	−3.9 (−7.1, −0.7)		−9.3 (−13.9, −4.8)		0.00 (−3.5, 4.4)
Crude IRR, (exact 95% CI)	0.23 (0.01, 1.44)		0.00 (0.00, 1.35)		1.18 (0.25, 11.09)

^*All incidence rate differences and incidence rate ratios are given as comparing use of efavirenz vs. use of nevirapine

EFV = efavirenz; NVP = nevirapine; PY = person-years; IR = incidence rate; IRR = incidence rate ratio; CI = confidence interval; ART = antiretroviral therapy