Appendix Table 4.
Factors associated with initiation of efavirenz as compared to nevirapine in marginal structural models
| Variable | Adjusted OR* (95% CI) | P-value |
|---|---|---|
| Baseline covariates | ||
| Age | ||
| ≤ 30 | REF | -- |
| 31–40 | 1.04 (0.66–1.63) | 0.87 |
| 41–50 | 1.14 (0.63–2.08) | 0.66 |
| > 50 | 1.31 (0.53–3.23) | 0.56 |
| Female | 0.81 (0.52–1.27) | 0.36 |
| Married | 1.01 (0.67–1.51) | 0.98 |
| Education | ||
| None | REF | -- |
| Some primary | 0.64 (0.36–1.14) | 0.136 |
| Completed primary | 0.90 (0.46–1.74) | 0.75 |
| Secondary or higher | 0.80 (0.42–1.51) | 0.49 |
| Asset index | ||
| 1st quintile (most poor) | REF | -- |
| 2nd quintile | 0.87 (0.07–10.91) | 0.91 |
| 3rd quintile | 0.26 (0.01–4.91) | 0.37 |
| 4th quintile | 0.42 (0.03–6.29) | 0.53 |
| 5th quintile (least poor) | 0.08 (0.004–1.52) | 0.093 |
| Year of enrollment | ||
| 2005–07 | REF | -- |
| 2008–10 | 1.09 (0.63–1.89) | 0.76 |
| 2011–13 | 28.66 (16.76–49.01) | < 0.001 |
| Depressed at enrollment | 0.91 (0.37–2.25) | 0.84 |
| Suicidal ideation at enrollment | 2.46 (0.61, 9.91) | 0.21 |
| Baseline CD4+ count (100 cells/μL) | 2.01 (1.46–2.77) | < 0.001 |
| Tuberculosis co-infection | 6.60 (3.34–13.06) | < 0.001 |
| Physical health summary score | ||
| 1st quartile (least healthy) | REF | -- |
| 2nd quartile | 1.65 (0.72–3.81) | 0.24 |
| 3rd quartile | 2.04 (0.74–5.66) | 0.169 |
| 4th quartile (most healthy) | 3.23 (1.05–9.96) | 0.041 |
| Heavy drinking | 1.40 (0.56–3.51) | 0.48 |
| Time-varying covariates | ||
| Previous asset index | ||
| 1st quintile (most poor) | REF | -- |
| 2nd quintile | 1.06 (0.08–13.33) | 0.97 |
| 3rd quintile | 3.02 (0.16–55.95) | 0.46 |
| 4th quintile | 2.47 (0.16–37.52) | 0.52 |
| 5th quintile (least poor) | 21.42 (1.18–387.97) | 0.038 |
| Previous depression | 1.50 (0.60–3.77) | 0.39 |
| Previous suicidal ideation | 0.48 (0.11–2.13) | 0.33 |
| Previous CD4+ count | 0.54 (0.39–0.74) | < 0.001 |
| Previous viral load suppression | 0.16 (0.08–0.32) | < 0.001 |
| Previous heavy drinking | 0.88 (0.33–2.37) | 0.81 |
| Previous physical health summary score | ||
| 1st quartile (least healthy) | REF | -- |
| 2nd quartile | 0.41 (0.18–0.94) | 0.036 |
| 3rd quartile | 0.38 (0.14–1.02) | 0.055 |
| 4th quartile (most healthy) | 0.28 (0.09–0.85) | 0.025 |
| ART duration (weeks) | 1.04 (0.88–1.21) | 0.66 |
OR = odds ratio; CD4+ = CD4+ T-cell lymphocyte; ART = antiretroviral therapy
*
OR > 1 favors initiation of EFV;
OR < 1 favors initiation of NVP