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. Author manuscript; available in PMC: 2020 May 21.
Published in final edited form as: Biochem Biophys Res Commun. 2019 Apr 2;513(1):166–171. doi: 10.1016/j.bbrc.2019.03.177

Figure 4. Schematic illustration of the mechanism.

Figure 4.

In normal collecting ducts ATP acts via P2Y and P2X receptors. However, in the developing cysts P2X receptors become more prevalent. Also, cystic epithelium enhances expression of pannexin-1 which is able to form a channel with P2X7 capable of facilitating ATP release into the cyst. High ATP levels promote cystogenesis by different mechanisms, particularly decreasing activity of ENaC-dependent reabsorption in cysts cells