Table 2:
Morphological characteristics in color fundus photographs at 1, 2, and 5 years in eyes with no scar, non-fibrotic scar, fibrotic scar and no scar at Year 1
| Characteristics on color fundus photographs and fluorescein angiogram | Scar Group | Year | P* | ||
|---|---|---|---|---|---|
| 1 | 2 | 5 | |||
| n (%) | n (%) | n (%) | |||
| Geographic atrophy, yes (%) | No scar (N=367) | 83 (23) | 95 (26) | 166 (45) | <0.0001 |
| Nonfibrotic scar (N=39) | 0 (0) | 2 (5) | 8 (21) | 0.02 | |
| Fibrotic scar (N=68) | 12 (18) | 16 (24) | 37 (54) | <0.0001 | |
| P§ | 0.0004 | 0.008 | 0.002 | ||
| Non-geographic atrophy, yes (%) | No scar (N=367) | 137 (42) | 167 (46) | 235 (72) | <0.0001 |
| Nonfibrotic scar (N=39) | 11 (34) | 18 (47) | 24 (65) | 0.04 | |
| Fibrotic scar (N=68) | 30 (49) | 33 (50) | 43 (73) | 0.009 | |
| P§ | 0.36 | 0.79 | 0.61 | ||
| Leakage on angiography, yes (%) | No scar (N=367) | 162 (45) | 120 (33) | 79 (25) | <0.0001 |
| Nonfibrotic scar (N=39) | 18 (50) | 11 (29) | 7 (20) | 0.02 | |
| Fibrotic scar (N=68) | 28 (43) | 15 (23) | 13 (22) | 0.006 | |
| P§ | 0.81 | 0.24 | 0.84 | ||
| CNV Lesion Size (mm2):mean (SD) | Nonfibrotic scar (N=39) | 2.6 (3.2) | 3.4 (4.3) | 5.8 (7.2) | 0.04 |
| Fibrotic scar (N=68) | 10.5 (9.4) | 10.4 (8.8) | 17.1 (12.0) | <0.0001 | |
| No scar (N=367) | 6.9 (6.7) | 7.7 (7.3) | 12.5 (10.8) | <0.0001 | |
| P§ | <0.0001 | <0.0001 | <0.0001 | ||
§
For the comparison of difference among three scar groups.
*
For the comparison of difference among three time points within a given scar group.
CNV = Choroidal neovascularization