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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Neuropharmacology. 2019 Mar 19;150:91–99. doi: 10.1016/j.neuropharm.2019.03.021

Figure 2.

Figure 2.

Ng expression in the mPFC regulates PPI response. A and B, Neither AAV-mediated oNg nor dnNg expression in the C57BL/6J mice induces any locomotor changes compared to those of AAV-GFP expression. C, Both AAV-dnNg expression in the mPFC of Ng +/+ mice and AAV-oNg expression in the mPFC of Ng −/− does not induce acoustic startle changes compared to AAV-GFP control mice. D, dnNg expression in the mPFC of Ng +/+ mice does not induce PPI change. E, oNg expression in the mPFC of Ng −/− mice demonstrate significantly increased PPI response compared to that of AAV-GFP expression in the mPFC of Ng −/− mice. Statistical significance was measured by one-way ANOVA followed by Tukey’s test. (n = 8 per group, C57BL/6J x129S1 cross). Data presented as mean ± SEM.