Table 5.
Univariable associations of baseline serum BAFF and its soluble receptors with SLE clinical parameters overtime
| AMS > 4 | Flare overtimea | Organ damage present at last visit | Damage accrual | |||||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P‐value | OR (95% CI) | P‐value | OR (95% CI) | P‐value | OR (95% CI) | P‐value | |
| Baseline serum BAFF | ||||||||
| Low (≤ median) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| High (> median) | 2.67 (1.1, 6.47) | 0.03 | 1.83 (0.73, 4.57) | 0.2 | 3.7 (1.39, 9.81) | <0.01 | 2.06 (0.72, 5.88) | 0.18 |
| Baseline serum sBCMA | ||||||||
| Low (≤ median) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| High (> median) | 0.46 (0.19, 1.1) | 0.08 | 0.44 (0.17, 1.11) | 0.08 | 0.54 (0.22, 1.36) | 0.19 | 0.64 (0.23, 1.81) | 0.4 |
| Baseline serum sTACI | ||||||||
| Low (≤ median) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| High (> median) | 0.68 (0.29, 1.61) | 0.38 | 1.19 (0.48, 2.94) | 0.7 | 0.84 (0.34, 2.07) | 0.7 | 0.64 (0.23, 1.81) | 0.4 |
| Baseline serum sBAFF‐R | ||||||||
| Low (≤ median) | 1.00 | 1.00 | 1.00 | 1.00 | ||||
| High (> median) | 1.32 (0.56, 3.13) | 0.53 | 1.83 (0.73, 4.57) | 0.2 | 0.97 (0.39, 2.39) | 0.94 | 0.68 (0.24, 1.92) | 0.47 |
AMS, adjusted mean SLE Disease Activity Index 2000; BAFF, B cell‐activating factor from the tumor necrosis factor family; BAFF‐R, BAFF receptor; BCMA, B cell maturation antigen; CI, confidence interval; OR, odds ratio; SLE, systemic lupus erythematosus; TACI, transmembrane activator and cyclophilin ligand interactor
a
Encompasses mild, moderate and severe flares.