Table 4.
Association of human epidermal growth factor receptor 2 gene status with clinicopathological features n (%)
| Clinicopathological features |
HER2 status |
P-value | |
| HER2 negative | HER2 positive | ||
| Gender | 0.441 | ||
| Male | 616 (96.2) | 24 (3.8) | |
| Female | 406 (97.1) | 12 (2.9) | |
| Age (yr) | 0.272 | ||
| ≤ 60 | 501 (96.0) | 21 (4.0) | |
| > 60 | 521 (97.2) | 15 (2.8) | |
| Tumor grade | 0.784 | ||
| 1 | 39 (97.5) | 1 (2.5) | |
| 2 | 773 (96.7) | 26 (3.3) | |
| 3 | 210 (95.9) | 9 (4.1) | |
| Histology | 0.762 | ||
| Tubular | 937 (96.5) | 34 (3.5) | |
| Mucinous/other types | 85 (97.7) | 2 (2.3) | |
| Tumor site | 0.819 | ||
| Colon | 548 (96.5) | 20 (3.5) | |
| Rectal | 474 (96.7) | 16 (3.3) | |
| Left-sided colon | 203 (88.3) | 27 (37.0) | 0.514 |
| Right-sided colon | 292 (86.4) | 46 (63.0) | |
| Depth of invasion | |||
| T1 | 31 (100.0) | 0 (0.0) | 0.039 |
| T2 | 165 (98.8) | 2 (1.2) | |
| T3 | 815 (96.3) | 31 (3.7) | |
| T4 | 11 (78.6) | 3 (21.4) | |
| T1-2 | 196 (99.0) | 2 (1.0) | 0.001 |
| T3-4 | 826 (96.0) | 34 (4.0) | |
| Lymph node metastasis | |||
| N0 | 541 (96.3) | 21 (3.7) | 0.260 |
| N1 | 261 (98.1) | 5 (1.9) | |
| N2 | 220 (95.7) | 10 (4.3) | |
| No | 541 (96.3) | 21 (3.7) | 0.524 |
| Yes | 481 (97.0) | 15 (3.0) | |
| Distant metastasis | 0.028 | ||
| No | 940 (96.9) | 30 (3.1) | |
| Yes | 81 (92.0) | 7 (8.0) | |
| Tumor stage | |||
| (1)I-II | 192 (98.5) | 2 (1.0) | 0.012 |
| III | 749 (96.5) | 27 (3.5) | |
| IV | 81 (92.0) | 7 (8.0) | |
| (3)I-II | 192 (99.0) | 2 (1.0) | 0.044 |
| III-IV | 830 (96.1) | 34 (3.9) | |
HER2: Human epidermal growth factor receptor 2.