Table 3.
Docetaxel pharmacokinetics
| Docetaxel PK parameters | Docetaxel (n = 18) | Docetaxel+prednisone (n = 18) | Relative difference (95% CI) | P‐value |
|---|---|---|---|---|
| AUC0‐inf a geomean ng*h/mL (CV%) | 2647 (22) | 2784 (27) | 1.9% (−9.9 till 15.2) | .75 |
| Cmax a geomean ng/mL (CV%) | 2454 (26) | 2505 (25) | −1.4% (−15.3 till 14.8) | .85 |
| CLa geomean, L/h (CV%) | 55 (26) | 53 (26) | −2.3% (−9.5 till 5–6) | .53 |
| T1/2 b median, h (IQR) | 12.6 (10.6–14.5) | 13.7 (11.3–16.3) | .31 |
AUC0‐inf = Area under curve timepoint zero until infinity; CI = confidence interval; CL = clearance; Cmax = maximum concentration; CV% = coefficient of variation; geomean = geometric mean; T1/2 = half‐life.
a
= analysed by means of a linear effect model,
b
= analysed by means of Wilcoxon signed rank test.