Table 2.
Population parameter estimates for base, final and bootstrap models
| Parameter | Base model [%RSE] | Final model [%RSE] | Bootstrap [95% CI] |
|---|---|---|---|
| CL/F (L/h) [θ*(FFM/55)0.75] | 12.4 [5.2] | 12.0 [5.0] | 12.0 [10.8–13.6] |
| CrCl covariate effect [*(CrCl/90)θ] | 0.224 [31.6] | 0.226 [0.046–0.396] | |
| Vd/F (L) [θ*(FFM/55)1.0] | 75.4 [5.1] | 68.8 [5.0] | 68.8 [61.8–76.3] |
| KTR (h−1) | 13.5 [5.8] | 13.5 [5.8] | 13.4 [11.9–36.8] |
| Correlation between CL/F and Vd/F | 0.856 | 0.862 | 0.870 [0.686–0.933] |
| BSV CL/F (%CV) | 55.3 [9.9] | 54.4 [10.7] | 54.2 [42.8–66.7] |
| BSV Vd/F (%CV) | 52.8 [9.9] | 53.3 [10.3] | 53.1 [43.0–64.6] |
| BSV KTR (%CV) | 60.7 [6.4] | 60.6 [6.4] | 60.8 [52.3–120] |
| Proportional RUV (%CV) | 43 [4.2] | 43 [4.2] | 43.1 [39.5–47.5] |
BSV, between‐subject variability; CI, confidence intervals; CL/F, apparent clearance; CrCl, creatinine clearance; FFM, fat free mass; KTR, transit rate constant; RUV, residual unexplained variability; Vd/F, apparent volume of distribution; θ, estimated parameter; %CV, percentage coefficient of variation; %RSE, percentage relative standard error.