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PK profiles in non‐pregnant and pregnant women. Simulation (mean predictions in black lines and 5th–95th percentiles of predictions in grey lines) of PK profiles for oral administration of 40 mg twice‐daily, in non‐pregnant situation and during the 6th, 20th and 34th weeks of pregnancy. Simulations were compared with the observed clinical data (circle) after 40 mg oral twice‐daily administration46
