Table 1.
Intraglomerular haemodynamics
R A (dyn/s/cm 5 ) | R E (dyn/s/cm 5 ) | P glom (mmHg) | |||||||
---|---|---|---|---|---|---|---|---|---|
Time point | VAS203 | Placebo | P‐value | VAS203 | Placebo | P‐value | VAS203 | Placebo | P‐value |
0 min | 1809 ± 572 | 1822 ± 576 | .945 | 2265 ± 329 | 2157 ± 264 | .292 | 64.2 ± 3.2 | 64.2 ± 3.0 | .984 |
120 min | 2290 ± 680 | 1541 ± 507 | <.001 | 2820 ± 390 | 2414 ± 544 | .016 | 65.7 ± 2.9 | 66.7 ± 4.4 | .412 |
240 min | 2175 ± 676 | 1528 ± 616 | .006 | 2899 ± 412 | 2507 ± 494 | .015 | 65.8 ± 3.3 | 67.8 ± 4.7 | .160 |
360 min | 2584 ± 829 | 1631 ± 664 | <.001 | 2885 ± 503 | 2464 ± 450 | .014 | 64.6 ± 3.7 | 66.8 ± 4.2 | .084 |
480 min | 2163 ± 732 | 1565 ± 564 | .017 | 2573 ± 381 | 2368 ± 406 | .139 | 64.5 ± 3.7 | 67.1 ± 5.4 | .110 |
Pglom, intraglomerular pressure; RA, resistance of the afferent arterioles; RE, resistance of the efferent arterioles.